Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis. The purpose of this study was to develop and evaluate curcuminloaded nano microparticulate systems to improve the solubility and stability of curcumin in gastrointestinal gi conditions. The term coacervationwas suggested for the first time by two dutch scientists38. The reason for this paradigm shift is due to the low development cost and time required for developing a ndds for the existing drugs rather developing a new drug molecule. Recently, biological data on the toxicity and pharmacokinetic behavior of various macromolecules has been compiled, and consequently very. Polymercoated longcirculating microparticulate pharmaceuticals v. Davis department of pharmaceutical sciences, university of nottingham, university park, nottingham ng7 2rd, uk accepted april 1995 abstract to exert its activity a drug must reach its pharmacological sites of actions. Marine drugs free fulltext novel spray dried glycerol. Specifically designed azo polymers or some natural polysaccharides such as chitosan, alginate, guar gum, dextran or amylose are employed as excipients to target the dissolution of the dosage form to the colon 28.
Microparticles offer various significant advantages as drug delivery systems, including. Longcirculating pegylated polycyanoacrylate nanoparticles. Biodegradable microparticulate drug delivery system of. In the form of ndds, existing drug molecule can get a new life, thereby increasing the market value and product patent life. Design, development and optimization abstract the purpose of the present research was to develop and characterize mucoadhesive microspheres of curcumin for the potential use of treating gastric adenocarcinoma. Furthermore, the role of active transport via organic cationic transporters octs was.
Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microsphere, nanoparticles etc, which modulates the release and absorption characteristics of the drug. Mucoadhesive microparticulate drug delivery system of curcumin against helicobacter pylori infection. Microparticles, microspheres, and microcapsules for advanced drug. Review on microparticulate drug delivery system request pdf. Pdf biodegradable microparticulate drug delivery system. The microparticles were developed as sustained delivery carriers for rifampicin in order to improve patient compliance in tuberculosis treatment in terms of reducing the dosing frequency. A lot of macromolecular prodrugs have been developed using various kinds of polymeric carriers, mainly in the field of cancer chemotherapy 1, 2, and found to be useful to control drug release, modify biodistribution or excretion and achieve drug targeting. The aim of this study was to evaluate the ability of longcirculating pegylated cyanoacrylate nanoparticles to diffuse into the brain tissue. Tb drug carriers to the alveoli milieu and infected macrophages, with potential to significantly improve the therapeutics efficiency.
Several type of microparticulate carriers have been employed in recent years in conjunction with a wide variety of drugs and a broad range of therapeutic goals. Annals of the new york academy of sciences, 01 jan 1987, 507. Nano and microparticulate carriers for pulmonary drug. So far, very few successful attempts have been made to deliver various drug carriers directly into the cell cytoplasm, bypassing the endocytic pathway, to protect drugs and dna from the lysosomal degradation, thus enhancing drug efficiency and dna incorporation into the cell genome 1114. They have been exploited for the dermal 1, peroral 100, parenteral 109, ocular, plumonary 83, and rectal 147 delivery. Davis, title long circulating microparticulate drug carriers. The wordcoacervationcomes from the latinacervus, meaning aggregation, and the prefixco,signifying the preceding union of the colloidal particles. A promising approach for the delivery of anti hiv drugs human immunodeficiency virus hiv is a retrovirus which causes acquired immuno deficiency. Biodegradable microparticulate drug delivery system of diltiazem hcl. As an additional benefit, the release profile of encapsulated drugs can be tailored to the respective medical needs by choosing an appropriate encapsulation material. Made up of polymeric, waxy, or other protective materials such as starches, gums, proteins, fats, and waxes and used as drug carrier matrices for drug delivery. Microparticulate drug delivery offers several applications for drugs having poor bioavailability. The present study deals with formulation of the alginate microparticles of rifampicin, an antitubercular agent. The controlled release of drugs in slow and sustained manner is one of the major challenges in drug delivery system.
Here, the development of a magnetically responsive microparticulate system for pulmonary delivery of an anti. Verified book library blu code for bulk carriers summary epub books. The principle of enzymatic degradation can also be extended to drug polymer conjugates or to drug carrier systems and dosage forms. One such formulation type that has already begun to fulfill its. Microparticles as controlled drug delivery carrier for the. Pdf microparticles as controlled drug delivery carrier. Davis department of pharmaceutical sciences, university of nottingham, university park, nottingham nc 7 2rd, uk. This barcode number lets you verify that youre getting exactly the right version or edition of a. Molecularparticulate drug carriers continued stealth particles announcements. Advanced drug delivery research, cibageigy pharmaceuticals, horsham, west sussex, united kingdom. Grenha and others published nano and microparticulate carriers for pulmonary drug delivery find, read and cite all the research you need on researchgate. Drug carriers may contain buffers to prevent medications from damaging body tissue. Biopharmaceutics of microparticulate drug carriers. Pegbased micelles as carriers of contrast agents for different imaging modalities.
Efficient carriers for intelligent nanoparticulate drug targeting and gene therapy. Stereocomplex formation between enantiomeric plapegpla triblock copolymers. These particulate systems are unique in terms of their particle size, as optimum particle size of carrier for localization of drug should be in the. This can be accomplished either by slow release of the drug over a long period of time typically diffusion or by triggered release at the. Polymers serving as drug carrier should be water soluble, nontoxic and nonimmunogenic. Microparticulate drug delivery systemsmultiunit carriers composed of spherical particles with average diameter 1500.
In this chapter i will briefly describe the physical characteristics and preparation of several types of. Drug carriers are primarily used to control the release of a drug into systemic circulation. Stable bonding between the carrier and drug prevent the drug from being released efficiently. Active targeting active targeting exploits modification or manipulation of drug carriers to redefine its biofate the natural distribution pattern of the drug carrier composites is enhanced using chemical, biological and physical means, so that it approaches and identified by particular biosites. Multiparticulate drug delivery systems for controlled release. In the present study, microparticles were prepared by cationinduced gelification of alginate.
Carrier based drug delivery is an alternative approach to improve the bioavailability of drugs while at the same time providing the necessary protection of drug molecules. In such case aquasomes proof to be worthy carrier, which are comprised of solid carriers whose film has been treated with a film of carbohydrate to prevent destructive denaturing interaction between drug. Stereocomplex formation between enantiomeric plapegpla. In vitro and in vivo evaluation of microparticulate drug. In the case of smart drug delivery microparticle systems, the release of the drug. Development of inhalable superparamagnetic iron oxide. Tremendous opportunities exist for utilizing advanced drug delivery systems for cancer treatments.
In recent years, particulate drug carriers include microparticulate, nanocarriers have been gaining an immense importance due to their wide advantages over existing systems gilhotra et al. Long circulating microparticulate drug carriers, adv. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to. Torchilin center for imaging and pharmaceutical research, department of radiology, massachusetts general hospital and harvard medical school 149, th street, charlestown, ma, 02129, usa. The drugs are often inevitable and these always bring limitation to drug delivery system.
Drug uptake by cells was studied with respect to deposited dose, drug solubility and hydrophobicity. Mucoadhesive microparticulate drug delivery system of. Biodistribution profiles and brain concentrations of 14cradiolabeled pegphdca, polysorbate 80 or poloxamine 908coated phdca nanoparticles, and uncoated phdca nanoparticles were determined by radioactivity counting after. One of the current approaches to achieve site specific delivery utilises the use of a carrier. Enzymatic or nonenzymatic cleavage of such a bond is needed in order to expect a pharmacological effect. The most important chemical features and biological behavioural characteristics of the carrier molecules exploited for drug. Another important issue is the safe excretion of the drug 1.
Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired area of action within the body. The deposition, dissolution and transport of salbutamol base sb and salbutamol sulfate ss inhalation powders were investigated using the calu3 air interface cell culture model and franz diffusion cell. Microspheres as drug delivery system linkedin slideshare. Inhalable polymeric dry powders are promising alternatives as anti. Nanocarriers are useful in the drug delivery process because they can deliver drugs to sitespecific targets, allowing drugs to be delivered in certain organs or cells but not in others. Thus, an understanding of the in vivo behavior of the drug carrier and its interaction with a number of critical biological systems becomes an important aspect of designing therapeutic strategies relying on microparticulate carriers. Among all, microparticulate system is one of the best approaches for controlled drug delivery in specific site of inflammation. Microparticles as controlled drug delivery carrier for the treatment of. Many drugs are toxic, and the toxic effects must balance with the therapeutic ones for the drug to be effective. Therapeutic applications drugs and the pharmaceutical. In many cases, enzymatic hydrolysis and phdependent hydrolysis have been utilized to achieve drug regeneration from carrier drug conjugates 4.
Use of polylactic acid for the preparation of microparticulate drug delivery systems. Designing polymeric microparticulate drug delivery system for. Molecules and particles as nano and microscale drug carriers. In addition, a large surface area of the microparticles. Review on microparticulate drug delivery system semantic. One of the most attractive areas of research in drug delivery today is the design of microparticulate systems that are able to deliver drugs to the right place, at. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Nano and microparticulate drug carriers for targeting of. They work passively in minimizing drug degradation and improving circulation time.
Microparticles, method of preparation, evaluation, material used. Based on their biodegradable, biocompatible, and nonimmunogenic structure. Controlled release delivery is available for many routes of administration and offers many advantages as microparticles and nanoparticles over immediate. Molecularparticulate drug carriers continued stealth. Nanoparticulates as drug carriers 1st edition by vladimir p torchilin editor isbn. Polymers in drug delivery scientific research publishing.
Sitespecificity is a major therapeutic benefit since it prevents drugs from being delivered to the wrong places. A versatile drug delivery carrier systems 1747 covalent bonds between polymer chains. Davis department of pharmaceutical sciences, university of nottingham, university park, nottingham nc 7 2rd, uk accepted april 1995 abstract. Even though this leads to more mechanical stability, some of the crosslinking agents used can be toxic, and give unwanted reactions, thus rendering the. Deposition, diffusion and transport mechanism of dry. Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microsphere, nanoparticles etc, which. Other drug carriers may attach to the drug molecules to make sure they only target certain kinds of cells, like cancer cells or bacteria. Targeting of drug to the particular site is an important aspect of drug delivery system. Rjpt alginatebased microparticulate oral drug delivery. Fabrication of microparticulate carrier systems for effectual delivery of atypical antipsychotic drug introduction antipsychotics also known as neuroleptics or major tranquilizers are a class of psychiatric medication primarily used to manage psychosis including delusions, hallucinations, or. To exert its activity a drug must reach its pharmacological sites of actions within the body.
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